BAX Antikörper (AA 1-192)

Produktnummer ABIN5700359

Der Kaninchen Polyklonal Anti-BAX-Antikörper wurde für WB, IHC, ELISA, IF, FACS und IP validiert. Er ist geeignet, BAX in Proben von Human, Maus, Ratte, Kaninchen und Schaf zu detektieren.

Kurzübersicht für BAX Antikörper (AA 1-192) (ABIN5700359)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human, Maus, Ratte, Kaninchen, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunoprecipitation (IP)

Produktdetails anti-BAX Antikörper

Bindungsspezifität: AA 1-192

Verwendungszweck: BAX antibody

Immunogen:

Immunogen sequence: 1-192aa

Immunogen: BCL2-associated X protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB : 1:1000-1:10000 IP : 1:1000-1:10000 IHC : 1:20-1:200 IF : 1:10-1:100

Kommentare:

HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00810(BAX antibody) at dilution of 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: BAX

Hintergrund:

Synonyms: Apoptosis regulator BAX|Bcl-2-like protein 4 (Bcl2-L-4)|BAX|BCL2L4

Background: BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction(PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria(PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis(PMID: 8183579).

Molekulargewicht: 21 kDa

Gen-ID: 581

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response